Cyklodextriner, med sin unika cykliska struktur och speciella fysiska och kemiska egenskaper, har visat stor tillämpningspotential inom området kromatografisk analys . Under de senaste åren har kontinuerliga nya framsteg gjorts i relaterad forskning .}
The hydrophobic interior and hydrophilic exterior of cyclodextrins enable them to form inclusion complexes with many compounds. This property is widely used in the preparation of chromatographic stationary phases. Bonding cyclodextrins and their derivatives to chromatographic column packings can significantly enhance the separation ability of the chromatographic column for different Ämnen . till exempel i gaskromatografi kan cyklodextrinbaserade stationära faser effektivt separera olika flyktiga föreningar, inklusive alkaner, alkoholer, estrar, etc .}
In liquid chromatography, cyclodextrins are more widely used, especially in the separation of chiral compounds. Enantiomers of chiral compounds often exhibit significant differences in biological activity and pharmacological effects. Accurate separation of enantiomers is crucial for fields such as drug research and development and food safety testing. Cyclodextrins can interact with chiral compounds through various forces, such as hydrophobic interactions, hydrogen bonds, and van der Waals forces, to form inclusion complexes with different stabilities, thus achieving the separation of chiral isomers. In addition, in supercritical fluid chromatography, cyclodextrin - based stationary phases also demonstrate excellent separation performance and can be used for the rapid analysis of complex prover .
With the deepening of research, new cyclodextrin derivatives are constantly being developed, and their combination with chromatographic techniques is becoming increasingly close. In the future, the application of cyclodextrins in chromatographic analysis is expected to develop towards high sensitivity, high selectivity, and automation, providing more efficient solutions for the separation and analysis of complex samples and playing a greater role in many fields such as life sciences and Miljöövervakning .
